Metastatic Squamous Neck Cancer is an extremely rare type of squamous cell cancer, which means that it has spread beyond the neck to distant organs in the body. Squamous cells are found in many parts of the body, including the thyroid, neck, tonsils, and base of the tongue. If not caught early enough, this disease can spread throughout the lymphatic system, and can eventually settle in the nasopharynx and tonsils.
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Although early-stage metastatic squamous neck cancers often have a better prognosis and are less likely to spread, the risk of recurrence increases in advanced cancer stages. However, with appropriate treatment, a patient can expect a longer survival time and a better chance of a full recovery. Although a full diagnosis is difficult, the care team may identify precancerous growths on the neck.
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Metastatic Squamous Neck Cancer may originate from one of the paranasal sinuses, the small hollow spaces surrounding the nose, and the neck. The major salivary glands are found in the floor of the mouth, near the jawbone. Metastatic Squamous Neck Cancer, however, is more likely to originate from the neck than from other locations in the body. This type of cancer often has an unknown primary, but can be detected with a biopsy.
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HNSCC is genetically unstable and frequently loses chromosomal regions. A model of ordered histological progression has enabled specific chromosomal abnormalities to be assigned to stages of progression. In particular, the loss of nine p21 is associated with the progression of the disease from normal head and neck mucosa to hyperplasia. Other genes affecting cellular function include p53 and cyclin D1.
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The combination of methotrexate, paclitaxel, and ifosfamide has shown significant efficacy against recurrent, platinum-resistant, or metastatic squamous cell cancer. However, there is no clear winner in the battle against Squamous Cell Cancer. As of January 2019, no drug has been shown to be better than a combination of these agents in clinical trials.
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Treatment of Squamous Cell Carcinoma is complex and often involves a variety of treatments. Treatments for the disease can range from surgery to radiation therapy. While undergoing chemotherapy, a patient should also be aware of the different aspects of the treatment process. This will help them decide which treatment method is best suited for their condition. This disease is extremely treatable, but the right treatment is necessary for a successful outcome.
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In addition to surgery, advanced minimally invasive surgical techniques, such as laser and transoral robotic resection, are available for high-risk patients. Systemic treatment with radiation and chemotherapy is also used when surgery is not an option. Advanced squamous cell cancer may require treatment with alternative therapies, including immunotherapy. Some studies have found that immunotherapy can increase the chances of cure in patients with high-risk tumors.
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Head and neck cancers usually originate in squamous cells that line the nose, mouth, throat, and sinuses. There is a strong association between HPV and Squamous Cell Carcinoma, but there are no known causes. It is important to get screened for this condition to determine the best course of treatment. In some cases, there may be no other symptoms associated with Squamous Cell Carcinoma.
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People with weakened immune systems are also at a higher risk for Squamous Cell Carcinoma. They may be exposed to the sun for a prolonged period of time. Furthermore, individuals with compromised immune systems are more likely to develop this disease than people without it. In addition, those with xeroderma pigmentosum, which affects the immune system, are more susceptible to Squamous Cell Carcinoma.
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Radiation therapy is the most common treatment for Squamous Cell Tumors in the neck. It involves the use of a computer-generated image of the tumor and delivers thin beams of radiation from different angles. Intensity-modulated radiation is less likely to cause side effects such as dry mouth, difficulty swallowing, and skin damage than other types of radiation. Another option for SCC is a type of internal radiation therapy using a radioactive substance.
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