Pancreatic neuroendocrine tumors are rare but dangerous diseases that can affect the body. They develop when the hormone-producing cells in the pancreas develop mutations in their DNA. DNA contains instructions for chemical processes in the body and when the DNA becomes mutated, the cells become abnormal and form tumors. These tumors can spread to nearby organs or blood vessels. Men are more likely to develop pancreatic neuroendocrine tumors than women.
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The symptoms of pancreatic neuroendocrine tumors can range from abdominal pain to a loss of appetite and other symptoms. While some symptoms may indicate the presence of a pancreatic neuroendocrine tumor, other diseases can cause similar symptoms. Therefore, it is important to see your healthcare provider as soon as you notice any of the symptoms. It's essential to get a proper diagnosis because symptoms of other conditions can mimic those of a pancreatic neuroendocrine tumor.
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Most pancreatic NETs spread to the liver. When they do, the cancer cells can release hormones directly into the blood. These hormones can cause other symptoms such as diarrhea, anemia, weight loss, and a rapid heartbeat. Other symptoms can include muscle weakness, nausea, and yellowing of the skin or eyes. Once diagnosed, symptoms of pancreatic neuroendocrine tumors will depend on their location.
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In addition to abdominal pain, some people experience indigestion. Inflammation and a blocked tube can block bile flow. Patients with pancreatic neuroendocrine tumors should seek medical attention if these symptoms persist or worsen. You may even have diarrhea or vomiting as a result of the tumors. But in most cases, these symptoms are non-specific and do not indicate the presence of cancer.
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The treatment of pancreatic neuroendocrine tumors may include a combination of treatments. One form of treatment, called debulking surgery, removes the tumor and surrounding tissues. Local treatment will help ease symptoms and slow the growth of the tumor, but will not cure the disease. But if the tumor has returned after surgery, there may not be any treatment options for it. For advanced cases, it may be deemed incurable.
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As a result, patients with these types of tumors may experience other symptoms, including a lack of appetite or weight. Pancreatic neuroendocrine tumors can be difficult to detect and treatment options vary. However, early diagnosis and treatment can help save lives. If you have any of these symptoms, you should see a medical professional. Your doctor can help you determine if you have pancreatic neuroendocrine tumors.
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Surgery is the most common treatment for a malignant tumor. Surgeons remove the tumor or other parts of the pancreas. In addition to surgery, patients may also receive chemotherapy to shrink the tumor. The survival rate of patients with pancreatic neuroendocrine tumors is higher than that of patients with common pancreatic cancers, based on studies from 2009-2015.
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Although most patients with pancreatic neuroendocrine tumors are benign, the symptoms may be hard to detect. Many of these patients experience hypoglycemia as their first sign. The patient may also experience personality changes or even seizures. In severe cases, the symptoms of hypoglycemia can cause seizures and coma. However, with early detection and treatment, the patient can lead a normal life.
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Intestinal NETs produce a substance called vasoactive intestinal peptide (VIP). This substance is associated with diarrhea that worsens over time. Diarrhea is the most common symptom of these tumors, but other symptoms may include vomiting, muscle cramps, fatigue, and flushing. Additionally, people with these tumors tend to have low stomach acid, which can result in difficulties digesting food.
