While neuroendocrine pancreatic tumors don't always cause symptoms, these conditions can result in stomach ulcers, weight loss, jaundice, and other complications. Nonfunctioning pancreatic NETs can cause similar symptoms to pancreatic duct adenocarcinoma, including pain, abdominal swelling, jaundice, and weight loss. Diagnosed during a routine checkup for a different problem, nonfunctioning pancreatic NETs are often more difficult to detect.
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While nonfunctional pancreatic NETs do not produce symptoms, they are often large and often have a high rate of cancer. Although pancreatic neuroendocrine tumors are rare, they are also more common than nonfunctional ones. The cause of pancreatic NETs is unclear, and it is best to seek medical advice from a doctor if you notice any of the following symptoms:
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Intestinal tumors produce a substance called vasoactive intestinal peptide (VIP), which causes diarrhea. Over time, this diarrhea will become more severe. Diarrhea is the most common symptom, but other symptoms include weakness, muscle cramps, flushing, and nausea. Patients may also experience low stomach acid levels, making digestion more difficult. This can lead to anemia and other health issues.
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Although neuroendocrine tumors of the pancreas are rare, early detection can help improve the chances of a cure. Surgery is the primary treatment for this disease. Early diagnosis can improve the chances of a patient's survival. The median survival time of people with neuroendocrine tumors depends on the location of the tumor. Surgery can remove the tumor and restore pancreatic function.
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Those suffering from pancreatic neuroendocrine tumors should see their doctor for a diagnosis. Symptoms of pancreatic neuroendocrine tumors can be caused by other health conditions, and a healthcare provider can determine the diagnosis by reviewing your medical history and conducting a physical examination. Blood tests can also reveal high levels of hormones. Once a diagnosis is made, your doctor can move on to a more comprehensive evaluation.
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Symptoms of pancreatic neuroendocrine tumors include watery diarrhea, weight loss, and a slow heart rate. Some patients may experience jaundice or a yellow tinge to the skin. Diarrhea may be watery or bloody, and facial flushing may occur. Imaging tests may be needed to diagnose pNET or whether the tumor has spread.
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Although most cases of pancreatic neuroendocrine tumors are unrelated to family history, those with a family history of the condition are at a higher risk. People with multiple endocrine neoplasia type 1 (MEN1) syndrome are at an increased risk of developing a pNEN. If you or someone you know suffers from these symptoms, it's important to seek an accurate diagnosis.
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Fortunately, there are a number of treatments for pancreatic neuroendocrine tumors. In addition to surgical resection, medical management is a common treatment for this condition. Radiation therapy can control symptoms in patients with metastatic pancreatic neuroendocrine tumors. A multidisciplinary endocrine tumor program includes endocrinologists, endocrine surgeons, and nuclear medicine specialists who work together to diagnose the disease.
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Glucagonomas are one of the most common types of pancreatic neuroendocrine tumors. They produce the hormone insulin, which regulates blood sugar levels. In addition to these symptoms, insulinomas can also affect other gut hormones, including glucagon. They can cause confusion, loss of appetite, and weakness. The tumor may also result in a tachycardia, which causes rapid heartbeat.
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Although there are no specific symptoms for each type of NET, symptoms vary widely. Some patients with carcinoid syndrome may experience diarrhea and occasional blushing. Pheochromocytoma causes hypertension, and pancreatic neuroendocrine tumors produce insulin, glucagon, and gastric promoting hormones. Patients with nonfunctioning neuroendocrine tumors may have no symptoms at all.
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Treatment for pancreatic neuroendocrine tumors includes surgery, radiation, and targeted therapy. Surgery is the most common form of treatment for pancreatic NETs. Depending on the size of the tumor, patients may undergo surgery. During surgery, surrounding tissues may need to be removed as well. Some patients may also need follow-up tests after treatment. The symptoms of pancreatic neuroendocrine tumors depend on the type of NET and its location.
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The symptoms of pancreatic neuroendocrine tumors are similar to those of other illnesses. In addition to these symptoms, patients who are experiencing any of these conditions should visit a physician immediately. A multidisciplinary team of specialists, including radiologists, oncologists, and endocrinologists, will be able to identify and treat their condition. The team at the University of Michigan is dedicated to diagnosing and treating rare pancreatic endocrine tumors.
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