Pancreatic Neuroendocrine Tumors Symptoms - Oren Zarif - Pancreatic Neuroendocrine

What are the symptoms of pancreatic neuroendocrine tumors (pNENs)? As their name suggests, these types of tumors develop in the cells that produce hormones in the pancreas. They occur when cells develop mutations in their DNA, which provides instructions for chemical processes in the body. The abnormalities in DNA cause the cells to grow out of control and form tumors. These tumors can then spread to other organs. PNENs are more common in men than in women.

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These tumors originate in the pancreas, which is about six inches long and shaped like a thin pear. It is made up of endocrine cells, known as islets, which produce hormones. The islet cells play a vital role in regulating blood sugar levels. A pancreatic neuroendocrine tumor in this area can cause the pancreas to produce too much insulin, causing symptoms such as blurred vision and a fast heartbeat.

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Patients with pNET should seek medical care right away. These symptoms can be confused with other health issues. Your healthcare provider can confirm pNET symptoms by examining you and reviewing your medical history. A doctor will also perform a physical exam to check for any signs or symptoms of pancreatic neuroendocrine tumors. Blood tests can also detect high levels of hormones in the blood.

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A pancreatic neuroendocrine tumor produces hormones and may produce skin rashes. Because the tumor affects a variety of hormones, it is often difficult to distinguish between functional and nonfunctional pancreatic neuroendocrine tumors. Although pancreatic neuroendocrine tumor symptoms are very similar to those of pancreatic adenocarcinomas, they differ from one another. For example, the symptoms of a functional NET will be much more prominent than those of a nonfunctional tumor.

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Luckily, most pancreatic neuroendocrine tumors are harmless, and treatments are available to help patients manage the symptoms of the disease. One drug, Afinitor (everolimus), was approved by the U.S. Food and Drug Administration in May 2011. It has shown a positive effect in patients with advanced cancer. The effectiveness of Afinitor is uncertain, however, but it does show promise for slowing tumor growth and reducing the chances of cancer recurrence.

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The symptoms of pancreatic neuroendocrine tumors can be quite distinct from those of other conditions, so you need to be tested for these to avoid mistaken diagnoses. Some common symptoms of pancreatic neuroendocrine tumors are abdominal pain, constipation, fatigue, nausea, jaundice, and gastrointestinal bleeding. In some cases, pancreatic neuroendocrine tumors don't cause symptoms but can cause other problems, including a recurrence of cancer.

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Intestinal tumors produce a substance called vasoactive intestinal peptide (VIP), which increases glucose in the blood. When the level of VIP in the blood becomes too high, it causes diarrhea that gets worse over time. However, there are also other symptoms associated with intestinal tumors. For example, patients with intestinal tumors may experience muscle cramps, a feeling of weakness, or even flushing. Furthermore, patients with these tumors usually have low stomach acid levels, which can lead to difficulty in digestion.

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A multidisciplinary approach is required for the treatment of pancreatic neuroendocrine tumors. The treatment of the tumor may involve medical management, surgical resection, and radiation therapy, depending on its size and location. In addition, specialized imaging techniques may be used. If the tumor is large, surgery is the most common method of treatment. A specialized imaging study may be necessary to rule out other conditions.

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A doctor will also grade the tumors by taking samples of the affected tissues. The cells are analyzed under a microscope to determine the grade of the cancer. The G1-pNEN is the most common type, with a poor prognosis. However, the symptoms of pNETs can vary greatly from person to person and are determined by the stage in which the tumor has spread.

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If the tumors have spread to nearby organs, treatment may be necessary to stop the tumor's growth. Pancreatic neuroendocrine tumor surgery may include multiple types of treatment, including radiotherapy and chemotherapy. For example, Whipple surgery removes a portion of the pancreas along with nearby lymph nodes, the stomach, and small intestine, and bile. Another treatment for pancreatic neuroendocrine tumors involves distal pancreatectomy, which removes the body and tail of the pancreas, and cytoreduction, which removes pancreatic cancer in the liver.

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NETs may cause varying symptoms. If they grow slowly and do not release too much hormone, there are no symptoms. As the tumour grows and releases hormones, however, signs and symptoms may appear. However, you should note that symptoms of NETs may also be related to other illnesses. Symptoms of pancreatic neuroendocrine tumors vary according to the location of the tumour and the type of hormones secreted by the tumor.