If you are concerned about any of these symptoms, you may have primary CNS lymphoma. Some of the symptoms are similar to those associated with other forms of the disease, but some have specific locations. The following is a comprehensive list of symptoms that you should look for in any patient who may have CNS lymphoma. It is important to seek early diagnosis and treatment. For additional information about lymphoma symptoms, visit your doctor's office.
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A patient with primary CNS lymphoma will often exhibit neuropsychiatric signs and symptoms. The tumor may affect the cerebrum, spinal cord, eyes, or leptomeninges. In 7% of patients, systemic lymphoma will occur before any neurologic symptoms appear. Patients may develop fever, night sweats, weight loss, or fatigue. Symptoms of primary CNS lymphoma include any or all of these signs.
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Treatment options for primary CNS lymphoma will vary according to your symptoms. The treatments used to treat this type of cancer can have some side effects and may require regular follow-up visits. For the best outcomes, patients must be younger than 60, have a stable immune system, and have no other serious medical conditions, such as AIDS. They may also need to undergo palliative care to ease the symptoms of their disease.
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If you experience any of the symptoms listed above, it is important to seek medical attention as soon as possible. Your doctor can perform a blood test to determine whether or not you have primary CNS lymphoma. This is important because some people with this type of cancer have extremely low CD4 cells in their blood, and those with low CD4 counts may have AIDS. A primary central nervous system lymphoma tumor can interfere with the brain and spinal cord.
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While most cases of primary CNS lymphoma are not life threatening, it can be painful. Patients may experience leg weakness, incontinence, and back pain. The condition can also lead to blurred vision or loss of vision. If you have any of these symptoms, your doctor may recommend a CT scan and other tests to determine the cause of the problem. In addition to physical examinations, your doctor will also ask about your medical history and your family history to rule out other conditions.
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PCNSL is a rare form of non-Hodgkin lymphoma. It starts in the brain, spinal cord, or meninges, and rarely spreads outside of the CNS. Most PCNSLs are B-cell lymphomas, although T-cell PCNSL is rare. PCNSL is more common in older adults, with an average age of 65 years.
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Treatment for primary CNS lymphoma varies and depends on the extent of the cancer and how advanced it is. Depending on the stage of the disease, treatment is often a combination of chemotherapy and radiation. Personalized medicine, advanced imaging techniques, and the latest clinical trials are available at Abramson Cancer Center. The Penn Brain Tumor Center is at the forefront of neuro-oncology and represents a world-class facility. The center's innovative approach translates research discoveries into innovative treatment.
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Typical peripheral nerve involvement is seen in about 90% of patients with primary spinal cord lymphoma. Associated constitutional symptoms are also common. Twenty-nine percent of patients experienced back pain as their presenting symptom. Forty-three percent of patients had lower motor neuron signs, such as flaccid paralysis. Further, the disease is associated with peripheral nerve roots, including the spinal cord, and cranial nerves.
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The signs and symptoms of primary CNS lymphoma will vary. It is a rare form of non-Hodgkin lymphoma, and the disease starts in another part of the body and spreads to the CNS. Treatment for primary CNS lymphoma differs from that for secondary CNS lymphoma. A doctor will assess your specific symptoms to determine the best course of action.
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While the exact causes of CNS lymphoma are not known, people with compromised immune systems are at a higher risk. HIV and organ transplants can weaken the immune system. HIV also increases the risk of lymphoma. In addition to HIV, Epstein-Barr virus and herpes simplex virus are also risk factors. Additionally, prolonged exposure to viruses that stimulate the immune system may increase the risk of developing primary central nervous system lymphoma.
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Successful treatment can prolong life by more than 44 months, but patients should be aware that it can cause significant neurological toxicity. Whole-brain radiation is the standard of care, but it can also be accompanied by chemotherapy. Standard systemic chemotherapy regimens may be ineffective in primary central nervous system lymphoma because they can't cross the blood-brain barrier. Fortunately, new approaches have been developed to treat this disease more effectively.