Patients with primary CNS lymphoma should seek early medical treatment to limit any complications. The symptoms of primary CNS lymphoma include changes in personality, vision, speech, and physical strength. These symptoms may increase rapidly and require urgent medical attention. If they continue to develop for more than a few weeks, they should see a doctor immediately. Depending on the extent of the disease, treatment may be more aggressive than other forms of lymphoma.
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A physical examination with a neurologist can be a crucial part of identifying the disease. The doctor may ask patients to answer questions about their current health and their family's medical history. They may also ask them to repeat a list of objects or translate common sayings. A doctor may also perform imaging tests to determine the presence of tumors or cancer cells in the brain or spinal cord.
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Although primary CNS lymphoma can resemble other forms of brain cancer, its symptoms are distinct. In many cases, these patients can't distinguish it from other types of brain cancer. Fortunately, Penn neurosurgeons use precision-guided minimally invasive biopsies to determine the nature of the tumor. Furthermore, genetic testing at the Center for Personalized Diagnostics will help determine the tumor's genetic signature, so that it can be treated with the proper treatment.
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The main treatment for primary CNS lymphoma is whole-brain irradiation. Some cancers respond to chemotherapy. Although the treatments for this cancer are still in their developmental stages, there is little hope for a cure. Survival rates for patients with this disease are under 5%. These figures are based on the survival rates of patients receiving more than 50 Gy of radiation, and fewer than 5% can survive that long.
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Patients with PCNSL are at risk for seizures. Seizures can occur if the disease has spread to the central nervous system. Patients with AIDS may also have a decreased immune system. Patients may also have a compromised immune system and may require organ transplants to survive. It is important to seek early medical care to identify any changes in the brain. The most common symptoms of PCNSL are:
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Although there is no specific treatment for primary central nervous system lymphoma, doctors may suggest chemotherapy to help cure the disease. However, patients must be medically fit to undergo this treatment. Some patients may have to stay in the hospital for some sessions of chemotherapy. Other treatments may be used to support the chemotherapy, such as growth factors and antibiotics to treat any underlying infections. If these treatments are ineffective, patients may require alternative therapies.
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While the exact cause of primary CNS lymphoma is unknown, people with compromised immune systems are at higher risk. People with HIV/AIDS, organ transplants, and certain medications may have a reduced immune system. However, a growing number of healthy people are also suffering from the disease. The symptoms of CNS lymphoma range from severe pain to memory loss. The best course of treatment will be based on your symptoms and the treatment that best meets your needs.
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In severe cases, primary CNS lymphoma can affect the brain or spinal cord. It may also affect the membranes of the eye or spinal cord, causing impaired vision. Some patients even suffer from personality changes. In addition to neurological symptoms, other symptoms of primary CNS lymphoma include fever, night sweats, weight loss, and vision changes. So, you need to talk to your doctor right away.
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The treatment of primary CNS lymphoma is very different from that of other lymphomas. The blood-brain barrier protects the brain from drugs and toxins, so there are few drugs that can pass through it. Several decades ago, the only effective treatment for primary CNS lymphoma was radiotherapy to the whole brain. Today, modern treatments overcome this barrier by using chemotherapy in high doses.
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The main symptoms of primary central nervous system lymphoma are a fever, fatigue, headaches, and confusion. Patients may also experience facial swelling, difficulty with balance, and difficulty with breathing. In most cases, these symptoms are not specific to the type of lymphoma they have. They may be caused by another disease and are nonspecific. If symptoms are unspecific, PCNSL may be a sign of something more serious.
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Most patients with PCNSL present with multiple lesions at the time of their first presentation. MRI of the brain reveals abnormalities in 64% of patients with concomitant lesions. A CSF cytology is positive in at least 27% of patients after three lumbar punctures. A biopsy of the CSF may be needed in some cases. While the diagnosis is not 100% certain, it can help in deciding how the patient should be treated.