Squamous neck cancer is a form of salivary gland cancer that affects approximately one in every 100,000 people in the United States each year. It originates in the glands that produce saliva, which are located near the jawbone. Although cancer does not start in the lymph nodes, it can spread to them if it is not detected early enough. Squamous neck cancer can be classified as either primary or metastatic.
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Treatment depends on the type of squamous neck cancer, and the extent of investigation. For occult primary squamous neck cancer, the treatment can be locoregional. If a patient has metastasized disease, however, the treatment will be different. The type of treatment depends on where the cancer has spread to. Patients can undergo chemotherapy or other treatments based on their symptoms and their age.
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Squamous neck cancer is often metastatic, although patients with an occult primary may have a similar diagnosis. The primary tumor may be cervical or esophageal, but doctors cannot always tell from which organ the cancer has spread. If the primary is unidentified, the cancer may be metastatic. This cancer should be diagnosed early and treated with a surgical or radiotherapy regimen.
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Molecular characterization of HNSCC has revealed that it is characterized by genetic instability. Using a model of ordered histological progression, specific chromosomal abnormalities have been assigned to each type of cancer. Loss of 9p21 occurs during the transition of normal head and neck mucosa to hyperplasia. Loss of these genes is associated with genomic amplification. In addition, loss of 17p13 or the gene TP53ba has been associated with the development of invasive HNSCC.
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In high-risk patients, radiation therapy may be added to surgery. Chemotherapy may be added to radiation if there is significant lymph node involvement or positive margins. Systemic treatment with chemotherapy and radiation may be an option for patients who are not surgical candidates. In addition, the development of immunotherapy drugs targeting the PD-1 receptor has demonstrated promising results in advanced squamous cell cancer. These treatments are currently being evaluated at Johns Hopkins University.
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Most head and neck cancers begin in squamous cells that line the surface of the nose, mouth, and throat. The cancer is called squamous cell carcinoma. While the salivary glands are not the most common site of cancer, many different types of cancer can start within them. Among these are invasive squamous cell carcinoma and adenoid cystic cancer. It is not known how much squamous cell carcinoma is in a person's saliva.
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Squamous cell carcinomas originate from the cells called squamous. Squamous cells can be found in many places on the body, including the scalp and mucous membranes. They can also develop in the genitals and lips. While Squamous neck cancers are rarely life-threatening, they can grow rapidly and spread to other areas of the body. Therefore, a proper diagnosis and treatment are important for patients diagnosed with this condition.
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Symptoms of Squamous cell skin cancer include an abnormal growth on the skin that does not heal. Other symptoms include a crusty or ulcerous sore or a wart. Patients with a weakened immune system are also at risk for the disease. These individuals are also more likely to develop a second occurrence of Squamous cell skin cancer, and people who are taking medications that suppress the immune system are also at a higher risk.
