Squamous neck cancer can affect both men and women equally. While 80% of all cases of the disease are curable, it is not uncommon for cancer to recur. Symptoms and treatment options will vary according to the type of cancer and the primary site. In the case of N1 disease, the disease may spread to lymph nodes in the neck, a condition called metastasis. Although the majority of cases of the disease are curable, the survival rate is not very high.
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Treatment for metastatic squamous neck cancer varies, depending on the location and stage of the primary disease. In early-stage metastatic squamous neck cancer, the cancer has not spread beyond the lymph nodes. However, cancer cells from the primary tumor may still be present. During treatment, doctors try to locate the primary tumor and treat it similarly. When metastatic disease involves lymph nodes in the neck, it is treated as if the cancer cells originated from the lung.
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The symptoms of metastatic squamous neck cancer can be very varied. It may begin with a painful neck lump, or it may be accompanied by other symptoms. The doctor may decide to perform several diagnostic tests or refer you to a specialized physician. The doctor will review your medical history and current symptoms, and may perform a physical exam, including a neck and head exam. If you notice a lump in the neck, your doctor may suggest further testing.
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Squamous neck cancer is a type of head and neck cancer, which begins in a layer of cells called flat squamous cells on the mucosal surfaces of the head and neck structures. Metastatic squamous neck cancer, on the other hand, is a rare form of squamous cell carcinoma that spreads to cervical lymph nodes in the neck. Because this type of cancer has no primary tumor, it poses a unique challenge to the treatment team.
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A biopsy, or skin sample from the area, may be used to diagnose SCC. This method is known as photodynamic therapy, and involves applying a photosensitizing substance to the area affected. The photodynamic therapy activates the medication in the area and kills the cancer cells. Another option is systemic drugs, which are approved by the FDA for the treatment of SCC. These drugs work throughout the body, and are commonly used for aggressive cases of the condition. Laser surgery is another way to treat SCC.
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In addition to its genetic makeup, HNSCC tumour cells must also be able to detach from the basement membrane. Inhibiting anoikis inhibits metastasis. As a result, tumour cells need to detach from the basement membrane to grow. The basement membrane contains growth factors that activate tumour cell signalling pathways and suppress anoikis. These growth factors are derived from tumour and endothelial cells.
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Squamous neck cancer may occur in the salivary glands, which are located below the tongue and in front of the jawbone. This type of cancer can also spread to lymph nodes in the neck, where it is known as metastatic squamous neck cancer. In addition to cancer of the neck, squamous cell cancer may also develop in the sinuses. Once cancer spreads to lymph nodes, the cancer has already spread throughout the body.
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Treatment for Squamous Neck Cancer depends on the type of cancer and the stage of the disease. External radiation therapy may be used to treat squamous neck cancer. The treatment may alter the thyroid gland, so blood tests will be taken to determine the effect of radiation therapy on thyroid hormone levels. The cancer cell in the neck may be removed and the lymph nodes treated. In some cases, radiation therapy will not be enough.
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In a 73-year-old man with HPV-positive HNSCC, he received deintensified intensity modulated radiotherapy to the oropharynx and retropharyngeal lymph nodes and weekly cisplatin. The patient is now disease-free for 4.5 years without complications. He is grateful for the opportunity to help other patients with Squamous Neck Cancer.
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Radiation may be used to treat metastatic squamous cell cancer in addition to chemotherapy and hyperfractionated radiation therapy. Patients who cannot tolerate chemotherapy or surgery may also receive cryotherapy to treat early squamous cell cancer. However, the treatment is only effective for early-stage cancer and may not be suitable for larger invasive tumors or other parts of the body. It is also important to consider the side effects of radiation and chemotherapy.
