What Are the Symptoms of Pancreatic Neuroendocrine Tumor (pNET)? These symptoms may be caused by a variety of other conditions. Your healthcare provider can determine the cause of your symptoms based on your health history and physical exam. Your healthcare provider may also order blood tests to determine the amount of high-quality hormones in your body. If these tests are positive for pNET, your doctor may recommend surgery to remove the tumor.
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At the time of diagnosis, the pancreatic tumor may be small and localized to the pancreas. It may have spread to nearby organs and blood vessels, such as the large intestine and the spleen. A biopsy may reveal a tumor that has metastasized to distant organs. Your doctor will likely prescribe surgery or other treatment options based on your condition and the extent of the spread of the tumor.
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Insulinomas are the most common type of pancreatic neuroendocrine tumor. They produce insulin, which regulates blood sugar levels by transporting glucose into the liver and fat cells. In some cases, insulinomas may cause symptoms of high blood sugar and abnormal rashes. Hypoglycemia can cause seizures, weakness, or even coma. Other symptoms of pancreatic neuroendocrine tumors include a loss of appetite and weight, and a feeling of thirst and frequent urination.
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As the pancreas is a gland, it has both endocrine and exocrine cells. The exocrine cells secrete hormones, including insulin and glucagon, which regulate the body's ability to absorb sugar and process carbohydrates. The secreted hormones regulate a variety of functions, such as digesting food. If the pancreas becomes damaged, it can lead to diabetes and other complications.
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Diarrhea is a common symptom of pNEN. This occurs because of an overproduction of the VIP, a substance secreted by the digestive system. If the condition is not treated, diarrhea can get worse. Other symptoms include muscle cramps, fatigue, and flushing. Moreover, pNENs tend to cause low stomach acid levels, making it difficult to digest food.
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Although the symptoms of pancreatic neuroendocrine tumours vary from person to person, there are certain common signs and symptoms to watch for. These symptoms could be caused by another health condition, so you should get a medical examination to rule out other causes of your symptoms. In addition to the above symptoms, pancreatic neuroendocrine tumours can also cause the following conditions:
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A 34-year-old male patient presented with a chest mass that revealed a mass in the thymus. A diagnosis of neuroendocrine tumors was made based on the mass' location, type of NET, and ability to be removed. While neuroendocrine neoplasms have been thought to be rare, their incidence has increased in recent years. Moreover, they are associated with various symptoms, including Cushing's disease and gastrointestinal bleeding.
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A pancreatic NET may be non-functional, meaning that it does not cause symptoms associated with hormone hypersecretion. Most patients with NET are diagnosed incidentally, during imaging for other reasons, or after the tumor has bulked. Patients with hormonal hypersecretion, on the other hand, typically have diverse and puzzling symptoms. Treatment recommendations for pancreatic neuroendocrine tumors will differ depending on the hormone secreted.
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There are two types of pancreatic neuroendocrine tumors, nonfunctional and functional. Nonfunctional PNETs do not cause symptoms, but produce hormones. Most commonly, the functional variety is insulinomas. Nonfunctional PNETs are more likely to be cancer than those produced by functional pancreatic tumors. However, both types can cause severe health problems. To date, healthcare providers do not know the exact cause of pancreatic neuroendocrine tumors.
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If your symptoms indicate a PNET, your doctor may recommend a diagnostic procedure. You may have a small biopsy or a minor exploratory surgery. The results of these tests may help your doctor diagnose the type of tumor and its progression. If your symptoms persist, your doctor may choose to remove the tumor. If your PNET is benign, your doctor may prescribe medications to treat your symptoms and monitor your health.
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The symptoms of pancreatic neuroendocrine tumors are largely similar to those of other disorders. A thorough examination, detailed history, and multidisciplinary assessment are essential for the correct diagnosis of pNEN. However, because pNENs often go undetected, they must be diagnosed in their early stages. If you are experiencing any of these symptoms, you should seek treatment immediately.
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The symptoms of pancreatic NETs depend on the type of hormone they secrete. Symptoms can vary depending on where they have spread. Carcinoid syndrome, for example, causes intermittent blushing and diarrhea. Pheochromocytoma, on the other hand, produces symptoms that are insulin-based, gastric-promoting, and hormonal. If your symptoms are not specific, you may be suffering from another type of cancer.
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